Subsequently, she acted alongside Mammootty in Bus Conductor, with Suresh Gopi in the films Adbutham (2006) and Lanka (2006), and alongside Jayaram in Madhuchandralekha (2006). She also played the heroine in Baba Kalyani with Mohanlal. Later that year, she debuted in the Tamil film industry, starring in the Karu Pazhaniappan-directed film Sivappathigaram opposite Vishal Krishna, which turned out to be only an average grosser.
In 2007 she acted with Mammootty in the blockbuster film Big B. She eventually stepped into the Telugu film industry as well, when she appeared in a supporting role in the film Yamadonga, directed by SS Rajamouli. The film became one of the biggest hits of the year. She had lent her voice for a couple of songs in this film too. In 2008, she appeared in 7 films, predominantly in Telugu-language films.
Her first release was her debut Kannada film Gooli. She then starred her first in the film Krishnarjuna, essaying the lead female role finally, which however did not well at the box office. Victory was her next assignment as lead actress, but that film also failed at the box office, following which she appeared in a cameo role in her only Tamil release that year, Kuselan, alongside Tamil superstar Rajinikanth. Three more Telugu releases featured Mamta, including Homam, directed by JD Chakravarthy and Srinu Vaitla’s King (2008 film) opposite Nagarjuna. In both these films she also performed as a playback singer in several songs.